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Daclizumab (TAB-023)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD25 Therapeutic Antibody (daclizumab) TAB-023 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to Human CD25. Daclizumab (trade name daclizumab) is a therapeutic humanized monoclonal antibody. It is used to prevent rejection in organ transplantation, especially in kidney transplants. The drug is also under investigation for the treatment of multiple sclerosis. Daclizumab works by binding to CD25, the alpha subunit of the IL-2 receptor of T cells.
  • Target
  • CD25
  • Type
  • IgG1 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in ELISA, Neut, IF, IP, FC, FuncS and most other immunological methods.
  • CAS
  • 152923-56-3
  • Trade name
  • daclizumab
  • Specificity
  • Tested positive against native human antigen
  • Protein Construction
  • Immunoglobulin G1,anti-(human interleukin 2 receptor) (human-mouse monoclonal clone 1H4 gamma 1-chain), disulfide with human-mouse monoclonal clone 1H4 light chain, dimer
  • Predicted N terminal
  • H Chain: QVQLVQSL Chain: DIQMTQS
  • Purity
  • >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Size
  • 1mg
  • Storage
  • Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

BACKGROUND

  • Antigen Description
  • CD25 is the alpha chain of the IL-2 receptor. It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2. Though CD25 has been used as a marker to identify CD4+FoxP3+ regulatory T cells in mice, it has been found that a large proportion of resting memory T cells constitutively express CD25 in humans. CD25 is expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, and tumor infiltrating lymphocytes. Its soluble form, called sIL-2R may be elevated in these diseases and is occasionally used to track disease progression.
  • Function
  • drug binding; interleukin-2 binding; interleukin-2 receptor activity; receptor activity;
  • Synonyms
  • IL2RA; interleukin 2 receptor, alpha; IL2R; interleukin-2 receptor subunit alpha; CD25; p55; IL2-RA; IL-2-RA; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha; TCGFR; IDDM10;

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