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"RG7116 is a glyco-engineered humanised monoclonal antibody that is designed to inhibit the activation and signalling of HER3, a member ofthe Human Epidermal Growth Factor Receptor (HER) family which amplifies cell survival and proliferation signals when associated with HER2or HER1. Through glyco-engineering HER3 MAb is designed to engage the immune system when bound to tumor cells and elicit enhancedantibody-dependent cellular cytotoxicity (ADCC)." – Roche pipelinegamma1 heavy chain (1-449) [humanized VH (Homo sapiens IGHV1-18*01 (89.80%) – (IGHD) – IGHJ4*01) [8.8.13] (1-120) – Homo sapiensIGHG1*01(CH1 (121-218), hinge (219-233), CH2 (234-343), CH3 (344-448), CHS K2>del (449)) (121-449)],(223-220') – disulfide withkappa light chain (1'-220') [humanized V-KAPPA (Homo sapiens IGKV4-1*01 (93.10%) -IGKJ2*01) [12.3.9] (1'-113') – Homo sapiens IGKC*01(114'-220')]; dimer (229-229":232-232") – bisdisulfide
>95.0% as determined by analysis by RP-HPLC.
CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular).
SH3/SH2 adaptor activity; coreceptor activity; identical protein binding; protease binding; protein binding; protein homodimerization activity;