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Ruplizumab (TAB-027)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD40L Therapeutic Antibody (Antova) TAB-027 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to Human CD40L. Ruplizumab (trade name Antova) is a humanized monoclonal antibody intended for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis. A study showed that the drug was associated with life-threatening thromboembolisms, while another study only found thrombocytopenia.
  • Target
  • CD40L
  • Type
  • IgG1 - kappa
  • Immunogen
  • Animals were immunized with D1.1 cells.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
  • CAS
  • 220651-94-5
  • Trade name
  • antova
  • Specificity
  • Tested positive against native human antigen
  • Protein Construction
  • Immunoglobulin G1,(anti-human CD40 ligand) (human-mouse monoclonal 5c8 gamma 1-chain), disulfide with human-mouse monoclonal 5c8 kappa-chain, dimer
  • Predicted N terminal
  • H Chain: QVQLVQSL Chain: DIVLTQS
  • Purity
  • >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

BACKGROUND

  • Antigen Description
  • Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
  • Function
  • CD40 receptor binding; cytokine activity; tumor necrosis factor receptor binding;
  • Synonyms
  • CD40LG; CD40 ligand; HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome); CD40 antigen ligand; CD40L; CD154; gp39; hCD40L; hyper IgM syndrome; T B cell activating molecule; TNF related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; CD40-L; T-cell antigen Gp39; T-B cell-activating molecule; TNF-related activation protein; IGM; IMD3; HIGM1; T-BAM; TNFSF5;

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