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dapirolizumab pegol (TAB-H16)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD40LG Therapeutic Antibody TAB-H16 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Humanized (from rat) antibody to Human CD40LG
  • Type
  • Fab' - G1 - kappa
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, WB and most other immunological methods.
  • CAS
  • 1416147-64-2
  • Specificity
  • CD40LG (CD40 ligand, CD40L, tumor necrosis factor ligand superfamily member 5, TNFSF5, tumor necrosis factor related activation protein, TRAP, CD154) [Homo sapiens]
  • Protein Construction
  • PEGylated antibodygamma1 heavy chain fragment VH – (CH1-hinge) (1-229) [humanized VH (Homo sapiens IGHV3-74*01 (76.50%) – (IGHD) – IGHJ1*01) [8.7.12](1-118) Homo sapiens IGHG1*01 (CH1 (119-216), hinge 1 11 (217-227)) (119-227) – dialanyl (228-229)], (221-214') – disulfidekappa light chain (1'-214') [humanized V- KAPPA (Homo sapiens IGKV1-NL1*01 (83.20%) – IGKJ1*01) [6.3.9] (1'-107') – Homo sapiens IGKC*01(108'-214')];conjugated via a linker of the maleimide group (thioether bond with cysteinyl h 11 (227)) to two linear chains of methoxy polyethylene glycol20 (mPEG20).
  • Purity
  • Purity >95% by SDS-PAGE.

BACKGROUND

  • Antigen Description
  • CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3.
  • Function
  • CD40 receptor binding; cytokine activity; tumor necrosis factor receptor binding;
  • Synonyms
  • CD40LG; CD40 ligand; HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome); CD40 antigen ligand; CD40L; CD154; gp39; hCD40L; hyper IgM syndrome; T B cell activating molecule; TNF related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; CD40-L; T-cell antigen Gp39; T-B cell-activating molecule; TNF-related activation protein; IGM; IMD3; HIGM1; T-BAM; TNFSF5;

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