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Arcitumomab (TAB-014-F(P))

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CEA therapeutic Antibody Fab Fragment (CEA-Scan) TAB-014-F(P) 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody Fragment Fab to Human CEA. Technetium (99mTc) arcitumomab is a drug used for the diagnostic imaging of colorectal cancers. It consists of the Fab' fragment of a monoclonal antibody (arcitumomab, trade name CEA-Scan) and a radionuclide, technetium-99m. Technetium (99mTc) arcitumomab is an immunoconjugate. Arcitumomab is a Fab' fragment of IMMU-4, a murine IgG1 monoclonal antibody extracted from the ascites of mice. The enzyme pepsin cleaves the F(ab')2 fragment off the antibody. From this, the Fab' fragment is prepared by mild reduction. Before application, arcitumomab is reconstituted with a solution of the radioactive agent sodium pertechnetate (99mTc) from a technetium generator.
  • Target
  • CEA
  • Type
  • Fab' - G1
  • Immunogen
  • Full length native protein (CEA)
  • Species Reactivity
  • Human
  • Expression Host
  • E. coli
  • Applications
  • Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
  • CAS
  • 154361-48-5
  • Trade name
  • cea-scan
  • Specificity
  • Tested positive against native human antigen
  • Protein Construction
  • Immunoglobulin G1, anti-(human carcinoembryonic antigen) Fab` fragment (mouse monoclonal gamma 1-chain), disulfide with mouse monoclonal light chain
  • Purity
  • >95.0% as determined by analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • At -20°C for one year.

BACKGROUND

  • Antigen Description
  • Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E. coli Dr adhesins.
  • Function
  • molecular_function; protein binding;
  • Synonyms
  • CEACAM1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); BGP; carcinoembryonic antigen-related cell adhesion molecule 1; BGP1; CD66a; antigen CD66; CD66a antigen; BGPI;

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