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emactuzumab (TAB-H23)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CSF1R Therapeutic Antibody TAB-H23 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Humanized antibody to Human CSF1R
  • Type
  • IgG1 - kappa
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, IHC and most other immunological methods.
  • CAS
  • 1448221-67-7
  • Specificity
  • CSF1R (colony stimulating factor 1 receptor, CSF-1R, CSF-1-R, macrophage colony-stimulating factor 1 receptor, c-fms, FMS, CD115) [Homo sapiens]
  • Protein Construction
  • gamma1 heavy chain (1-446) [humanized VH (Homo sapiens IGHV1-18*01(92.90%) – (IGHD) – IGHJ6*01) [8.7.10] (1-116) – Homo sapiens IGHG1*01 (CH1(117-214), hinge (215-229), CH2 (230-339), CH3 (340-444), CHS (445-446))(117-446)], (219-213') – disulfide withkappa light chain (1'-213') [humanized V-KAPPA (Homo sapiens IGKV1-39*01(86.30%) -IGKJ2*01) [6.3.8] (1'-106') -Homo sapiens IGKC*01 (107'-213')]; dimer(225-225":228-228")-bisdisulfideUnclear if this is the same as one of the other CSF-1R mAbs – no directsequence match
  • Purity
  • Purity >95% by SDS-PAGE.

BACKGROUND

  • Antigen Description
  • Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded, in humans, by the CSF1R gene. It is a receptor for a cytokine called colony stimulating factor 1.
  • Function
  • ATP binding; cytokine binding; cytokine binding; macrophage colony-stimulating factor receptor activity; nucleotide binding; protein homodimerization activity; receptor activity;
  • Synonyms
  • CSF1R; colony stimulating factor 1 receptor; FMS, McDonough feline sarcoma viral (v fms) oncogene homolog; macrophage colony-stimulating factor 1 receptor; C FMS; CD115; CSFR; CSF-1-R; CD115 antigen; CSF-1 receptor; FMS proto-oncogene; proto-oncogene c-Fms; macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; FMS; FIM2; HDLS; C-FMS; CSF-1R; M-CSF-R;

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