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Mavrilimumab (TAB-096)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CSF2RA Recombinant Antibody TAB-096 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to CSF2RA. Mavrilimumab is a human monoclonal antibody designed for the treatment of rheumatoid arthritis.
  • Target
  • CSF2RA
  • Type
  • IgG4 - lambda2
  • Immunogen
  • Human GM-CSF Receptor alpha transfected COS cells.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
  • CAS
  • 1085337-57-0
  • Specific Activity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G4-lambda, anti-[Homo sapiens CSF2RA (granulocyte-macrophage colony-stimulating factor receptor subunit alpha, GM-CSF-R-alpha, CD116)], Homo sapiens monoclonal antibody;gamma4 heavy chain (1-447) [Homo sapiens VH (IGHV1-24*01 (93.80%) -(IGHD)-IGHJ3*02) [8.8.13] (1-120) -IGHG4*01 (121-447)], (134-216")-disulfide with lambda light chain (1"-217") [Homo sapiens V-LAMBDA (IGLV1-40*01 (87.90%) -IGLJ2*01) [9.3.11] (1"-111") -IGLC2*01 (112"-217")]; (226-226"":229-229"")-bisdisulfide dimer
  • Predicted N terminal
  • H Chain: QVQLVQS; L Chain: QSVLTQP
  • Molecular Weight
  • 143200
  • Purity
  • >95%, by SDS-PAGE with silver staining, under reducing conditions.
  • Size
  • 1mg
  • Storage
  • Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

BACKGROUND

  • Antigen Description
  • Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
  • Function
  • cytokine receptor activity; receptor activity;
  • Synonyms
  • CSF2RA; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage); CSF2R; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; CD116; GMR-alpha; GMCSFR-alpha; CD116 antigen; GM-CSF receptor alpha subunit; colony stimulating factor 2 receptor alpha subunit; granulocyte-macrophage colony-stimulating factor receptor alpha chain; GMR; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; MGC3848; MGC4838; GM-CSF-R-alpha;

Related Products

All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.

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