Mavrilimumab
DESCRIPTION |
CATALOG # |
SIZE |
PRICE |
Anti-Human CSF2RA Therapeutic Antibody |
TAB-096 |
1mg |
Please Inquiry |
Product Detail
- Cat
- TAB-096
- Product Overview
- Recombinant monoclonal antibody to CSF2RA. Mavrilimumab is a human monoclonal antibody designed for the treatment of rheumatoid arthritis.
- Target
- CSF2RA
- Type
- IgG4 - lambda2
- Immunogen
- Human GM-CSF Receptor alpha transfected COS cells.
- Species Reactivity
- Human
- Expression Host
- CHO
- Applications
- Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
- CAS
- 1085337-57-0
- Specificity
- Tested positive against native human antigen.
- Protein Construction
- Immunoglobulin G4-lambda, anti-[Homo sapiens CSF2RA (granulocyte-macrophage colony-stimulating factor receptor subunit alpha, GM-CSF-R-alpha, CD116)], Homo sapiens monoclonal antibody;gamma4 heavy chain (1-447) [Homo sapiens VH (IGHV1-24*01 (93.80%) -(IGHD)-IGHJ3*02) [8.8.13] (1-120) -IGHG4*01 (121-447)], (134-216")-disulfide with lambda light chain (1"-217") [Homo sapiens V-LAMBDA (IGLV1-40*01 (87.90%) -IGLJ2*01) [9.3.11] (1"-111") -IGLC2*01 (112"-217")]; (226-226"":229-229"")-bisdisulfide dimer
- Predicted N terminal
- H Chain: QVQLVQS; L Chain: QSVLTQP
- Molecular Weight
- 143200
- Purity
- >95%, by SDS-PAGE with silver staining, under reducing conditions.
- Size
- 1mg
- Storage
- Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
- Antigen Description
- Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
- Function
- cytokine receptor activity; receptor activity;
- Gene ID
- 1438
- Synonyms
- CSF2RA; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage); CSF2R; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; CD116; GMR-alpha; GMCSFR-alpha; CD116 antigen; GM-CSF receptor alpha subunit; colony stimulating factor 2 receptor alpha subunit; granulocyte-macrophage colony-stimulating factor receptor alpha chain; GMR; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; MGC3848; MGC4838; GM-CSF-R-alpha;
- Download Datasheet:
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