Mavrilimumab

Cat

TAB-096

Product Overview

Recombinant monoclonal antibody to CSF2RA. Mavrilimumab is a human monoclonal antibody designed for the treatment of rheumatoid arthritis.

Target

CSF2RA

Type

IgG4 - lambda2

Immunogen

Human GM-CSF Receptor alpha transfected COS cells.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.

CAS

1085337-57-0

Specificity

Tested positive against native human antigen.

Protein Construction

Immunoglobulin G4-lambda, anti-[Homo sapiens CSF2RA (granulocyte-macrophage colony-stimulating factor receptor subunit alpha, GM-CSF-R-alpha, CD116)], Homo sapiens monoclonal antibody;gamma4 heavy chain (1-447) [Homo sapiens VH (IGHV1-24*01 (93.80%) -(IGHD)-IGHJ3*02) [8.8.13] (1-120) -IGHG4*01 (121-447)], (134-216")-disulfide with lambda light chain (1"-217") [Homo sapiens V-LAMBDA (IGLV1-40*01 (87.90%) -IGLJ2*01) [9.3.11] (1"-111") -IGLC2*01 (112"-217")]; (226-226"":229-229"")-bisdisulfide dimer

Predicted N terminal

H Chain: QVQLVQS; L Chain: QSVLTQP

Molecular Weight

143200

Purity

>95%, by SDS-PAGE with silver staining, under reducing conditions.

Size

1mg

Storage

Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Antigen Description

Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

Function

cytokine receptor activity; receptor activity;

Gene ID

1438

Synonyms

CSF2RA; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage); CSF2R; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; CD116; GMR-alpha; GMCSFR-alpha; CD116 antigen; GM-CSF receptor alpha subunit; colony stimulating factor 2 receptor alpha subunit; granulocyte-macrophage colony-stimulating factor receptor alpha chain; GMR; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; MGC3848; MGC4838; GM-CSF-R-alpha;

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