Ipilimumab

Cat

TAB-067

Product Overview

Recombinant monoclonal antibody to CTLA4. Ipilimumab (known as MDX-010 and MDX-101), marketed as Yervoy, is a drug used for the treatment of melanoma, a type of skin cancer. It is a U.S. Food and Drug Administration (FDA) approved human monoclonal antibody, and works by activating the immune system by targeting CTLA-4.
Cytotoxic T lymphocytes (CTLs) can recognize and destroy cancer cells. However, there is also an inhibitory mechanism that interrupts this destruction. Ipilimumab turns off this inhibitory mechanism and allows CTLs to continue to destroy cancer cells.

Target

CTLA4

Type

IgG1 - kappa

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in ELISA, IP, FC, FuncS, Neut, IF and most other immunological methods.

CAS

477202-00-9

Trade name

yervoy

Specificity

Tested positive against native human antigen.

Protein Construction

Immunoglobulin G1, anti-(human CTLA-4 (antigen)) (human γ1-chain), disulfide with human kappa-chain, dimer

Molecular Weight

148634

Purity

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Size

1mg

Storage

4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Antigen Description

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

Function

protein binding;

Gene ID

1493

Synonyms

CTLA4; cytotoxic T-lymphocyte-associated protein 4; celiac disease 3 , CELIAC3; cytotoxic T-lymphocyte protein 4; CD; CD28; CD152; GSE; ICOS; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; GRD4; CTLA-4; IDDM12; CELIAC3;

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