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Recombinant monoclonal antibody to ErbB3. Patritumab (INN) is a human monoclonal designed for the treatment of cancer. It acts as an immunomodulator.
IgG1 - kappa
HER3 ECD protein
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
Tested positive against native human antigen.
Immunoglobulin G1-kappa, anti-[Homo sapiens ERBB3 (receptor tyrosine-protein kinase erbB-3, HER3)], Homo sapiens monoclonalantibody; gamma1 heavy chain (1-447)-disulfide with kappa light chain (1"-220")-bisdisulfide dimer
Predicted N terminal
H chain: QVQLQQW; L chain: DIEMTQS
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Binds and is activated by neuregulins and NTAK.
ATP binding; growth factor binding; growth factor binding; nucleotide binding; protein binding; protein heterodimerization activity; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; NOT pr