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Patritumab (TAB-189)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human ERBB3 Therapeutic Antibody TAB-189 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to ErbB3. Patritumab (INN) is a human monoclonal designed for the treatment of cancer. It acts as an immunomodulator.
  • Target
  • ERBB3
  • Type
  • IgG1 - kappa
  • Immunogen
  • HER3 ECD protein
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
  • CAS
  • 1262787-83-6
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G1-kappa, anti-[Homo sapiens ERBB3 (receptor tyrosine-protein kinase erbB-3, HER3)], Homo sapiens monoclonalantibody; gamma1 heavy chain (1-447)-disulfide with kappa light chain (1"-220")-bisdisulfide dimer
  • Predicted N terminal
  • H chain: QVQLQQW; L chain: DIEMTQS
  • Purity
  • >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Size
  • 1mg
  • Storage
  • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

BACKGROUND

  • Antigen Description
  • Binds and is activated by neuregulins and NTAK.
  • Function
  • ATP binding; growth factor binding; growth factor binding; nucleotide binding; protein binding; protein heterodimerization activity; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; NOT pr
  • Synonyms
  • ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033;

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