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The Anti-ErbB2/HER2 Protein A Scaffold molecule is a highly specific affinity ligand selected against the extra cellular domain of HER2. The molecule is conjugated with maleimide activated horseradish peroxidase (HRP) at the unique C-terminal cysteine. The HRP-Conjugated Anti-HER2 Protein A Scaffold molecule is excellent for immunohistochemical staining of frozen tissue sections. Staining of paraffin embedded tissues is not recommended.
Immunohistochemical staining of frozen tissue sections.
Anti-HER2 Protein A scaffold molecule binds to extracellular domain of human epidermal growth factor receptor 2 (HER2). Cross reactivity with other species has not been tested.
At -20°C. Avoid freezing. There is no decrease in performance of the HRP-Conjugated Protein A Scaffold molecule after storage for 1 week in room temperature.
The human epidermal growth factor receptor HER2 (Her2/neu, ErbB2, or c-erb-b2) is a growth factor receptor that is expressed on many cell types. HER2-proteins are overexpressed in a number of cancer types and assemble in homo- or heterodimers to form functional signaling units. When overexpressed, homo- or heterodimers of HER2 cause increased proliferation, decreased apoptosis, enhanced tumor cell motility and neo-angiogenesis-all being traits strongly associated with tumor formation. Thus, the her2 gene is considered an oncogene.
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.