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Vantictumab (TAB-880)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Frizzled receptor Therapeutic Antibody TAB-880 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant human monoclonal antibody expressed in CHO binding to human Frizzled receptor. Vantictumab is a monoclonal antibody designed for the treatment of cancer.
  • Target
  • Frizzled receptor
  • Type
  • IgG2 - lambda
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
  • CAS
  • 1345009-45-1
  • Predicted N terminal
  • EVQLVESG
  • Molecular Weight
  • 142.5 kDa
  • Purity
  • >95.0% as determined by analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

BACKGROUND

  • Introduction
  • Vantictumab is a monoclonal antibody designed for the treatment of cancer.
  • Antigen Description
  • Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
  • Function
  • G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor activity; receptor binding; signal transducer
  • Synonyms
  • FZD1; frizzled family receptor 1; frizzled (Drosophila) homolog 1 , frizzled 1, seven transmembrane spanning receptor , frizzled homolog 1 (Drosophila); frizzled-1; DKFZp564G072; frizzled; Drosophila; homolog of; 1; Wnt receptor; fz-1; fzE1; hFz1; frizzled homolog 1; frizzled, Drosophila, homolog of, 1; frizzled 1, seven transmembrane spanning receptor; FLJ95923;

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