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Recombinant human monoclonal antibody expressed in CHO binding to human Frizzled receptor. Vantictumab is a monoclonal antibody designed for the treatment of cancer.
IgG2 - lambda
The details of the immunogen for this antibody are not available.
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
Predicted N terminal
>95.0% as determined by analysis by SDS-PAGE.
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Vantictumab is a monoclonal antibody designed for the treatment of cancer.
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor activity; receptor binding; signal transducer