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codrituzumab (TAB-H14)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human GPC3 Therapeutic Antibody TAB-H14 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Humanized antibody to Human GPC3
  • Type
  • IgG1 - kappa
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
  • CAS
  • 1365267-33-9
  • Specificity
  • GPC3 (glypican 3) [Homo sapiens]
  • Protein Construction
  • "RG7686 is a first in class monoclonal humanized anti-glypican 3 antibody being developed as single agent and in combination againstmetastatic hepatocellular carcinoma. Its therapeutic activity in pre-clinical models was shown to take place via antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP)." – Roche pipelinegamma1 heavy chain (1-445) [humanized VH (Homo sapiens IGHV1-46*01 (82.70%) – (IGHD) – IGHJ5*02) [8.8.8] (1-115) – Homo sapiensIGHG1*01 (CH1 (116-213, hinge (214-228), CH2 (229-338), CH3 (339-443), CHS (444-445)) (116-445)], (218-219')-disulfide withkappa light chain (1'-219') [humanized V-KAPPA (Homo sapiens IGKV2-28*01 (86.00%) -IGKJ2*01) [11.3.9] (1'-112') – Homo sapiens IGKC*01(113'-219')]; dimer (224-224":227-227") – bisdisulfide
  • Purity
  • >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.

BACKGROUND

  • Antigen Description
  • This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.
  • Function
  • heparan sulfate proteoglycan binding; peptidyl-dipeptidase inhibitor activity; protein binding;
  • Synonyms
  • GPC3; glypican 3; SDYS; glypican-3; DGSX; glypican proteoglycan 3; OCI 5; SGB; SGBS; SGBS1; secreted glypican-3; intestinal protein OCI-5; heparan sulphate proteoglycan; MXR7; OCI-5; GTR2-2;

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