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Ganitumab (TAB-199)

Datasheet
DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IGF-I Therapeutic Antibody TAB-199 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to IGF-I. Ganitumab is a human monoclonal antibody against type 1 insulin-like growth factor receptor (IGF1R), designed for the treatment of cancers.
  • Target
  • IGF-I
  • Type
  • IgG1 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
  • CAS
  • 905703-97-1
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G1-kappa, anti-[Homo sapiens IGF1R (insulin-likegrowth factor 1 receptor, IGF1-R, IGF-1R, CD221)], Homo sapiensmonoclonal antibody;gamma1 heavy chain (1-449) [Homo sapiens VH (IGHV4-4*02(100.00%) -(IGHD)-IGHJ3*02) [9.7.12] (1-119) -IGHG1*01 (120-449)], (222-219")-disulfide with kappa light chain (1"-219") [Homosapiens V-KAPPA (IGKV2-28*01 (95.00%) -IGKJ1*01) [11.3.9] (1"-112") -IGKC*01 (113"-219")]; (228-228"":231-231"")-bisdisulfide dimer
  • Predicted N terminal
  • H chain: QVQLQES; L chain: DVVMTQS
  • Molecular Weight
  • 145700
  • Purity
  • >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at -20°C. Avoid multiple freeze/thaw cycles.

BACKGROUND

  • Antigen Description
  • The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
  • Function
  • growth factor activity; hormone activity; hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; integrin binding; protein binding;
  • Synonyms
  • IGF1; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; IGF1A; MGF; IGF-IA; IGF-IB; somatomedin-C; mechano growth factor; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; IGFI; IGF-I;

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