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Recombinant monoclonal antibody to IGF1 Receptor. Figitumumab (previously CP-751871) is a monoclonal antibody targeting the insulin-like growth factor-1 receptor being investigated for the treatment of various types of cancer, for example adrenocortical carcinoma and non-small cell lung cancer (NSCLC).
IgG2 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in WB, ELISA, FC, IP, FuncS, IF, Neut and most other immunological methods.
Tested positive against native human antigen.
Immunoglobulin G2, anti-(human insulin-like growth factor I receptor) (human monoclonal CP-751,871 clone 2.13.2 heavy chain) disulfide with human monoclonal CP-751,871 clone 2.13.2 light chain, dimer
>95.0% as determined by analysis by SDS-PAGE.
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins.
ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; nucleo