Teprotumumab

Cat

TAB-151

Product Overview

Recombinant monoclonal antibody to IGF1. Gantenerumab is a monoclonal antibody for the treatment of Alzheimer's disease. A phase I clinical trial has been conducted in 2006/07. Gantenerumab is currently being evaluated in a prodromal Alzheimer's Disease population in the Scarlet Road study, a global phase II study of approximately 360 subjects in 100 centers in 15 countries.

Target

IGF1

Type

IgG1

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.

CAS

89957-37-9

Specificity

Tested positive against native human antigen.

Protein Construction

Immunoglobulin G1, anti-(human beta-amyloid proteins 42 and 40) human monoclonal antibody

Predicted N terminal

H chain: QVELVES; L chain: EIVLTQS

Molecular Weight

145600

Purity

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Size

1mg

Storage

Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

Antigen Description

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

Function

growth factor activity; hormone activity; hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; integrin binding; protein binding;

Gene ID

3479

Synonyms

IGF1; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; IGF1A; MGF; IGF-IA; IGF-IB; somatomedin-C; mechano growth factor; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; IGFI; IGF-I;

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