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Recombinant monoclonal antibody to Human IgE. Omalizumab is a recombinant DNA-derived humanized IgG1k monoclonal antibody that specifically binds to free human immunoglobulin E (IgE) in the blood and interstitial fluid and to membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing B lymphocytes. Unlike an ordinary anti-IgE antibody, omalizumab does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells. IgE is commonly involved in type I hypersensitivity, which manifests the most prevalent allergic diseases. It has been estimated that as high as 20 to 40% of the populations who live a western lifestyle in economically advanced countries are affected by allergy and seek medical help. In the U.S., 8% of adults and 10% of children have asthma. While allergy occurs more frequently in individuals with higher serum IgE levels, such a correlation is only statistical and not absolute. Some allergic individuals have very low serum IgE, and some people with very high IgE have no allergic problems.
IgG1 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in WB, ELISA, IP, FC, FuncS, Neut, IF and most other immunological methods.
Tested positive against native human antigen
Immunoglobulin G1,anti-(human immunoglobulin E Fc region) (human-mouse monoclonal E25 clone gamma-chain), disulfide with human-mouse monoclonal E25 clone kappa-chain, dimer
Predicted N terminal
H chain: EVQLVESL chain: DIQLTQS
>95%, by SDS-PAGE with silver staining, under reducing conditions.
At -20°C for one year.
IgE is a member of the immunoglobulin family that mediates allergic responses such as asthma, food allergies, type 1 hypersensitivity and the familiar sinus inflammation suffered on a widespread basis. IgE is secreted by, and expressed on the surface of, B-cells.