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Gevokizumab (TAB-161)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IL1 beta Therapeutic Antibody TAB-161 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to IL1 beta. Gevokizumab is a humanized monoclonal antibody used in the treatment of diabetes and inflammatory disorders.
  • Target
  • IL1 beta
  • Type
  • IgG2 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.
  • CAS
  • 1129435-60-4
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G2-kappa, anti-[Homo sapiens IL1B (interleukin 1 beta, 1L1F2, IL-1B)], humanized monoclonal antibody
  • Predicted N terminal
  • H chain: QVQLQES; L chain: DIQMTQS
  • Molecular Weight
  • 145200
  • Purity
  • >95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

BACKGROUND

  • Antigen Description
  • Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaggedlandin and collagenase from synovial cells.
  • Function
  • cytokine activity; cytokine activity; growth factor activity; interleukin-1 receptor binding; protein domain specific binding;
  • Synonyms
  • IL1B; interleukin 1, beta; interleukin-1 beta; IL 1B; IL1 BETA; IL1F2; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; IL-1; IL1-BETA;

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