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Recombinant monoclonal antibody to IL17A. Crenezumab is a humanized monoclonal antibody against human 1-40 and 1-42 Beta amyloid, which is being investigated as a treatment of Alzheimer's disease.
IgG2 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
Tested positive against native human antigen.
Immunoglobulin G2, anti-(human interleukin-17 receptor A (IL-17RA, CDw217, CD217)); human monoclonal AMG827 γ2 heavy chain (130-214")-disulfide with human monoclonal AMG827 kappa light chain dimer (218-218"":219-219"":222-222"":225-225"")- tetrakisdisulfide
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Store at -20°C. Avoid multiple freeze/thaw cycles.
Interleukin 17 Receptor Alpha is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.