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Recombinant monoclonal antibody to integrin alpha 4 beta 7. Etrolizumab is a humanized monoclonal antibody designed for the treatment of inflammatory bowel disease.
Integrin alpha 4 beta 7
IgG1 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
Tested positive against native human antigen.
Immunoglobulin G1, anti-(human integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) and human integrin alpha-E/beta-7 (HML-1 antigen)); humanized rat monoclonal rhuMAb Beta7 des-447-lysine(CH3107K)-γ1 heavy chain (220-214")-disulfide with humanized rat monoclonal rhuMAb Beta7 kappa1 light chain, dimer (226-226"":229-229"")-bisdisulfide
Predicted N terminal
H chain: EVQLVES; L chain: DIQMTQS
>95.0% as determined by analysis by RP-HPLC.
At -20°C for one year.
Integrin alpha 4 beta 7, also known as, the lymphocyte Peyer"s patch adhesion molecule (LPAM1) is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer"s patches and intestinal lamina propria.
fibronectin binding; protein binding; receptor activity;