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Volociximab (TAB-077)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Integrin alpha 5 beta 1 Therapeutic Antibody TAB-077 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to Integrin Integrin alpha 5 beta 1. Volociximab (also known as M200) is a chimeric monoclonal antibody jointly for treatment of a variety of advanced solid tumors. It binds to and inhibits the functional activity of α5β1 integrin.
    It is thought to reduce metastases. Early results show potential in renal cell cancers.
  • Target
  • Integrin alpha 5 beta 1
  • Type
  • IgG4
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
  • CAS
  • 558480-40-3
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G4, anti-(human a5b1 integrin) (human-mouse clone p200-M heavy chain), disulfide with human-mouse clone p200-M k-chain, dimer
  • Predicted N terminal
  • H Chain: MAVLGLL; L Chain: MDFQVQV
  • Molecular Weight
  • 145500
  • Purity
  • >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

BACKGROUND

  • Antigen Description
  • This protein belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha V chain. Alpha chain V undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
  • Function
  • integrin binding; platelet-derived growth factor receptor binding; protein binding; receptor activity; vascular endothelial growth factor receptor 2 binding;
  • Synonyms
  • ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); FNRA; integrin alpha-5; CD49e; VLA-5; integrin alpha-F; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronectin receptor, alpha subunit; very late activation protein 5, alpha subunit; VLA5A;

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