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Recombinant Mouse antibody to Human MS4A1. Ibritumomab tiuxetan, sold under the trade name Zevalin, is a monoclonal antibody radioimmunotherapy treatment for relapsed or refractory, low grade or transformed B cell non-Hodgkin's lymphoma, a lymphoproliferative disorder. The drug uses the monoclonal mouse IgG1 antibody ibritumomab (pronounced as ) in conjunction with the chelator tiuxetan, to which a radioactive isotope (either yttrium-90 or indium-111) is added. Tiuxetan is a modified version of DTPA whose carbon backbone contains an isothiocyanatobenzyl and a methyl group.
IgG1 - kappa
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
MS4A1(membrane-spanning 4-domains subfamily A member 1, CD20) [Homo sapiens]
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. In humans CD20 is encoded by the MS4A1 gene.