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sofituzumab vedotin (TAB-H63)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human MUC16 Therapeutic Antibody TAB-H63 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Humanized antibody to Human MUC16
  • Type
  • IgG1 - kappa
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
  • CAS
  • 1418200-58-4
  • Specificity
  • MUC16 (mucin 16, MUC-16, cancer antigen 125, CA125) [Homo sapiens]
  • Protein Construction
  • ADC with MMAE from Seattle Geneticsgamma1 heavy chain (1-446) [humanized VH (Homo sapiens IGHV3-48*03 (79.80%) – (IGHD) – IGHJ4*01) [9.8.9] (1-116) – Homo sapiensIGHG1*03 (CH1 R120>K (213) (117-214), hinge (215-229), CH2 (230-339), CH3 (340-444), CHS (445-446)) (117-446)], (219-214') – disulfidekappa light chain (1'-214') [humanized V- KAPPA (Homo sapiens IGKV1-5*01 (87.90%) – IGKJ1*01) [6.3.9] (1'-107') – Homo sapiensIGKC*01 (108'-214')]; dimer (225-225":228- 228") – bisdisulfide
  • Purity
  • >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.

BACKGROUND

  • Antigen Description
  • CA-125 (cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) also known as mucin 16 or MUC16 is a protein that in humans is encoded by the MUC16 gene. MUC16 is a member of the mucin family glycoproteins. CA-125 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, or other benign conditions.
  • Function
  • protein binding;
  • Synonyms
  • MUC16; mucin 16, cell surface associated; mucin-16; CA125; FLJ14303; CA-125; MUC-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;

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