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Recombinant monoclonal antibody to 5AC. Ensituximab is a chimeric monoclonal antibody used in the treatment of cancers.
IgG1 - kappa
M1 mucin preparation from the fluid of an ovarian mucinous cyst.
Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
Tested positive against native human antigen.
Immunoglobulin G1-kappa, anti-[Homo sapiens MUC5AC (mucin5AC, mucin 5 subtypes A and C tracheobronchial/gastric)], chimericmonoclonal antibody;gamma1 heavy chain (1-443) [Mus musculus VH (IGHV2-3*01 -(IGHD)-IGHJ4*01) [8.7.7] (1-113) -Homo sapiens IGHG1*01 CH1L85.3>P, CH3 T81>M (114-443)], (216-213")-disulfide with kappalight chain (1"-213") [Mus musculus V-KAPPA (IGKV4-70*01 -IGKJ1*01) [5.3.9] (1"-106") -Homo sapiens IGKC*01 (107"-213")];(222-222"":225-225"")-bisdisulfide dimer
Predicted N terminal
H chain: QVQLKES; L chain: QVVLTQS
>95.0% as determined by analysis by RP-HPLC.
At -20°C for one year.
Mucins are high molecular weight glycoproteins with 80% carbohydrates and 20% core protein. Gastric Mucin 5AC antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. Resurgence of gastric mucin during colonic carcinogenesis is suggestive of either re-expression of the peptide core of gastric mucin in the adult colon or due to changes in the glycosylation pattern of mucin, which expose the hidden Mucin 5AC antigen.