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N248A has distince HCVR and highly similar LCVR as the INN brontictuzumab record. N248A may be the mouse mAb before humanizationgamma2 heavy chain (1-447) [humanized VH (Homo sapiens IGHV1-24*01 (80.40%) – (IGHD) – IGHJ4*01 L123>T (116)) [8.8.14] (1-121) – Homosapiens IGHG2*01 (CH1 (122-219), hinge (220-231), CH2 (232-340), CH3 (341-445), CHS (446-447)) (122-447)],(135-214') – disulfide withlambda light chain (1'-215') [humanized V-LAMBDA (Homo sapiens IGLV7-46*01 (83.20%) -IGLJ2*01) [9.3.9] (1'-109') – Homo sapiens IGLC7*01(110'-215')]; dimer (223-223'':224-224'':227-227'':230-230'') – tetrakisdisulfide
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995
calcium ion binding; chromatin DNA binding; core promoter binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;