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brontictuzumab (TAB-H11)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human NOTCH1 Therapeutic Antibody TAB-H11 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Humanized (from mouse) antibody to Human NOTCH1
  • Type
  • IgG2 - lambda
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
  • CAS
  • 1447814-75-6
  • Specificity
  • NOTCH1 (notch 1, translocation-associated notch-1, TAN-1, TAN1) [Homo sapiens]
  • Protein Construction
  • N248A has distince HCVR and highly similar LCVR as the INN brontictuzumab record. N248A may be the mouse mAb before humanizationgamma2 heavy chain (1-447) [humanized VH (Homo sapiens IGHV1-24*01 (80.40%) – (IGHD) – IGHJ4*01 L123>T (116)) [8.8.14] (1-121) – Homosapiens IGHG2*01 (CH1 (122-219), hinge (220-231), CH2 (232-340), CH3 (341-445), CHS (446-447)) (122-447)],(135-214') – disulfide withlambda light chain (1'-215') [humanized V-LAMBDA (Homo sapiens IGLV7-46*01 (83.20%) -IGLJ2*01) [9.3.9] (1'-109') – Homo sapiens IGLC7*01(110'-215')]; dimer (223-223'':224-224'':227-227'':230-230'') – tetrakisdisulfide
  • Purity
  • >95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.

BACKGROUND

  • Antigen Description
  • Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995
  • Function
  • calcium ion binding; chromatin DNA binding; core promoter binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
  • Synonyms
  • NOTCH1; notch 1; Notch (Drosophila) homolog 1 (translocation associated) , Notch homolog 1, translocation associated (Drosophila) , TAN1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated; translocation-associated notch protein TAN-1; hN1; TAN1;

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