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Olaratumab (TAB-192)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human PDGF-R alpha Therapeutic Antibody TAB-192 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to PDGF-R alpha. Olaratumab is a monoclonal antibody which is for the treatment of solid tumors. It is directed against the platelet-derived growth factor receptor alpha.
  • Target
  • PDGF-R alpha
  • Type
  • IgG1 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
  • CAS
  • 1024603-93-7
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G1-kappa, anti-[Homo sapiens PDGFRA (plateletderivedgrowth factor receptor alpha subunit, CD140a, PDGFR2)],Homo sapiens monoclonal antibody
  • Predicted N terminal
  • H chain: QLQLQES; L chain: EIVLTQS
  • Molecular Weight
  • 147200
  • Purity
  • Purity >95% by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

BACKGROUND

  • Antigen Description
  • Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2.
  • Function
  • ATP binding; nucleotide binding; phosphatidylinositol 3-kinase binding; platelet-derived growth factor alpha-receptor activity; platelet-derived growth factor alpha-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor
  • Synonyms
  • PDGFRA; platelet-derived growth factor receptor, alpha polypeptide; platelet-derived growth factor receptor alpha; CD140a; PDGFR2; PDGFR-alpha; PDGF-R-alpha; CD140a antigen; PDGFRA/BCR fusion; CD140 antigen-like family member A; platelet-derived growth factor receptor 2; alpha-type platelet-derived growth factor receptor; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; CD140A; PDGFR-2; RHEPDGFRA; MGC74795;

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