Bavituximab

Cat

TAB-175

Product Overview

Recombinant monoclonal antibody to phosphatidylserine. Bavituximab is a chimeric monoclonal antibody designed for the treatment of cancers and viral infections.

Target

phosphatidylserine

Type

IgG1 - kappa

Immunogen

Liposomes containing 70% phosphatidylserine and 30% phosphatidylglycerol.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.

CAS

648904-28-3

Specificity

Tested positive against native human antigen.

Protein Construction

Immunoglobulin G1,anti-(phosphatidylserine) (human-mouse monoclonal ch3G4 heavy chain), disulfidewith human-mouse monoclonal ch3G4 k-chain, dimer

Predicted N terminal

H chain: EVQLQQS; L chain: DIQMTQS

Molecular Weight

145300

Purity

>95.0% as determined by analysis by SDS-PAGE.

Size

1mg

Storage

Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Introduction

Chimeric monoclonal antibody designed for the treatment of cancers and viral infections.

Antigen Description

Phosphatidylserine (abbreviated Ptd-L-Ser or PS) is a phospholipid component, usually kept on the inner-leaflet (the cytosolic side) of cell membranes by an enzyme called flippase. When a cell undergoes apoptosis, phosphatidylserine is no longer restricted to the cytosolic part of the membrane, but becomes exposed on the surface of the cell.

Keywords

Phosphatidylserine; PS; Ptd-L-Ser

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