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Atinumab (TAB-242)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human RTN-4 Therapeutic Antibody TAB-242 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to RTN-4. Atinumab is an immunomodulator. It binds to reticulon 4.
  • Target
  • RTN-4
  • Type
  • IgG4 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in WB, Neut, ELISA, IF, IP, FuncS, FC and most other immunological methods.
  • CAS
  • 1226761-65-4
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G4-kappa, anti-[Homo sapiens RTN4 (reticulon 4, neurite outgrowth inhibitor, NOGO), isoform A], Homo sapiens monoclonal antibody
  • Predicted N terminal
  • H chain: EVQLVES; L chain: EIVLTQS
  • Purity
  • >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Size
  • 1mg
  • Storage
  • Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

BACKGROUND

  • Antigen Description
  • Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
  • Function
  • protein binding; protein complex binding;
  • Synonyms
  • RTN4; reticulon 4; reticulon-4; ASY; KIAA0886; NOGO; NSP CL; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog; NSP; NOGOC; RTN-X; NOGO-A; NSP-CL; Nogo-B; Nogo-C; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545;

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