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Recombinant monoclonal antibody to TNF alpha. Golimumab (CNTO 148) is a human monoclonal antibody which is used as an immunosuppressive drug, Golimumab targets tumor necrosis factor alpha (TNF-alpha), a pro-inflammatory molecule and hence is a TNF inhibitor. Golimumab is as a once monthly subcutaneous treatment for adults with moderately to severely active rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
IgG1 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, WB and most other immunological methods.
Tested positive against native human antigen.
Immunoglobulin G1, anti (human tumor necrosis factor) (human monoclonal CNTO148 heavy chain), disulfide with human monoclonal CNTO148 light chain), dimer
Predicted N terminal
H Chain: QVQLVES; L Chain: EIVLTQS
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
cytokine activity; identical protein binding; protease binding; protein binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding;