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The Anti-TNF-α Protein A Scaffold molecule was selected against human TNF-α. The molecule is immobilized on agarose at the unique C-terminal cysteine. The Agarose-Immobilized Anti-TNF-α Protein A Scaffold molecule is excellent for immunoprecipitation studies of TNF-α present in cell extracts or other solutions that contain TNF-α proteins. In addition, the Anti-TNF-α Protein A Scaffold molecule may also be used for affinity chromatography.
Anti-TNF-α Protein A scaffold molecule binds to human cytokine tumor necrosis factor α, TNF-α. Cross reactivity with other species has not been tested.
At +4°C. Avoid freezing. There is no decrease in performance of the Agarose-Immobilized Protein A Scaffold molecule after storage for 2 weeks at +37°C.
Human TNF-α (Tumour Necrosis Factor-alpha) is a nonglycosylated protein of 17 kD belonging to the TNF superfamily of cytokines. TNF-α is produced by activated macrophages and Tlymphocyte and forms trimers spontaneously. TNF-α shows a wide spectrum of biological activities that are mediated by binding to TNFRI and TNFRII receptors. Besides causing cytolysis and cytostasis of many tumour cell lines in vitro, TNF-α has an important role in host defences against pathogens. However, excess TNF-α seen in sepsis and diseases of autoimmune character, has severe pathological consequences and the neutralisation of TNF-α has been a successful treatment procedure for rheumatoid arthritis.
cytokine activity; identical protein binding; protease binding; protein binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding