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Recombinant monoclonal antibody to TNF-alpha. Ozoralizumab is a humanized monoclonal antibody designed for the treatment of inflammatory diseases.
VH - VH' - VH
Full length native protein (purified) (Human).
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.
Tested positive against native human antigen.
Immunoglobulin single chain VH-VH"-VH, trivalent bispecific anti-[Homo sapiens TNF (tumor necrosis factor, TNF superfamily member 2, TNFSF2, TNFA, TNF-alpha)] VH and anti-[Homo sapiens ALB (albumin, human serum albumin, HSA)] VH", humanized Lama glama monoclonal antibody
Predicted N terminal
H chain: EVQLVES
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
cytokine activity; identical protein binding; protease binding; protein binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding;