Ranibizumab

Cat

TAB-012-F(E)

Product Overview

Recombinant monoclonal antibody Fragment Fab to Human VEGF. Ranibizumab (trade name ranibizumab) is a monoclonal antibody fragment (Fab) derived from the same parent mouse antibody as bevacizumab (bevacizumab). It is much smaller than the parent molecule and has been affinity matured to provide stronger binding to VEGF-A. It is an anti-angiogenic that has been approved to treat the "wet" type of age-related macular degeneration (AMD, also ARMD), a common form of age-related vision loss.

Target

VEGF

Type

Fab - G1 - kappa

Immunogen

Purified intact human VEGF

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, IHC and most other immunological methods.

CAS

347396-82-1

Trade name

ranibizumab

Specificity

Tested positive against native human antigen

Protein Construction

Immunoglobulin G1, anti-(human vascular endothelial growth factor) Fab fragment

Purity

>95.0% as determined by analysis by SDS-PAGE.

Size

1mg

Storage

Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

Antigen Description

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.

Function

cell surface binding; chemoattractant activity; cytokine activity; cytokine activity; extracellular matrix binding; fibronectin binding; growth factor activity; growth factor activity; heparin binding; heparin binding; platelet-derived growth factor recep

Gene ID

7422

Synonyms

VEGFA; vascular endothelial growth factor A; vascular endothelial growth factor , VEGF; VEGF A; VPF; vascular permeability factor; VEGF; MVCD1; MGC70609;

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