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Caplacizumab (TAB-234)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Von Willebrand Factor Recombinant Antibody TAB-234 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to Von Willebrand Factor. Caplacizumab (INN) is a humanized monoclonal that binds to VWF.
  • Target
  • Von Willebrand Factor
  • Type
  • VH - VH
  • Immunogen
  • Full length protein (Human)
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in WB, FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
  • CAS
  • 915810-67-2
  • Specific Activity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin VH-linker-VH fragment, anti-[Homo sapiens VWF (von Willebrand factor) A1 domain], humanized monoclonal antibody; VH-linker-VH chain (1-259) [humanized VH (Homo sapiens IGHV3-23*04 (82.50%) -(IGHD)-IGHJ4*01 L123>Q [8.8.21] (1-128)) - trialanyl linker (129-131) -[humanized VH (Homo sapiens IGHV3-23*04 (82.50%) -(IGHD)-IGHJ4*01 L123>Q [8.8.21] (132-259) anti-von Willebrand factor
  • Predicted N terminal
  • EVQLVES
  • Purity
  • Purity >95% by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

BACKGROUND

  • Antigen Description
  • Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
  • Function
  • chaperone binding; collagen binding; glycoprotein binding; immunoglobulin binding; integrin binding; protease binding; protease binding; protein N-terminus binding; protein binding; protein homodimerization activity;
  • Synonyms
  • VWF; von Willebrand factor; F8VWF; coagulation factor VIII VWF; VWD;

Related Products

All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.

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