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Romosozumab (TAB-116)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human scleroscin Therapeutic Antibody TAB-116 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to scleroscin. Romosozumab is a humanized monoclonal antibody designed for the treatment of osteoporosis.
  • Target
  • SOST
  • Type
  • IgG2 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
  • CAS
  • 909395-70-6
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G2-kappa, anti-[Homo sapiens SOST (sclerostin)], humanized monoclonal antibody
  • Predicted N terminal
  • H chain: EVQLVQS; L chain: DIQMTQS
  • Molecular Weight
  • 145900
  • Purity
  • Purity >95% by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at -20°C. Avoid multiple freeze/thaw cycles.

BACKGROUND

  • Antigen Description
  • Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antaggedonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
  • Function
  • heparin binding; protein binding; transcription factor binding;
  • Synonyms
  • SOST; sclerostin; sclerosteosis; VBCH;

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