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anifrolumab (TAB-722)

DESCRIPTION CATALOG # SIZE PRICE
Anti-IFNAR Therapeutic Antibody TAB-722 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant human monoclonal antibody expressed in CHO binding to human interferon α/β receptor. Anifrolumab is a monoclonal antibody designed for the treatment of systemic lupus erythematosus.
  • Target
  • interferon α/β receptor
  • Type
  • IgG1 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • NSO mouse myeloma cells
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, IHC and most other immunological methods.
  • CAS
  • 1326232-46-5
  • Predicted N terminal
  • EVQLVQSG
  • Molecular Weight
  • 145.12 kDa
  • Purity
  • >95.0% as determined by analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

BACKGROUND

  • Introduction
  • The interferon-α/β receptor (IFNAR) is a receptor which binds type I interferons including interferon-α and -β. It is a heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2.[2]It is a cell surface receptor. Binding of cytokine follows a JAK-STAT signaling pathway. Interferon stimulation results in an immunologic response that is especially associated with viruses.
  • Antigen Description
  • The interferon-α/β receptor (IFNAR) is a receptor which binds type I interferons including interferon-α and -β. It is a heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. It is a cell surface receptor.
  • Keywords
  • interferon-α/β receptor; IFNAR

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