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dalotuzumab (TAB-736)

DESCRIPTION CATALOG # SIZE PRICE
Anti-IGF1R Therapeutic Antibody TAB-736 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant humanized (from mouse) antibody expressed in CHO binding to IGF1R. Dalotuzumab is a humanized monoclonal antibody designed for the treatment of cancers.
  • Target
  • IGF1R
  • Type
  • IgG1 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
  • CAS
  • 1005389-60-5
  • Predicted N terminal
  • QVQLQESG
  • Molecular Weight
  • 146.4 kDa
  • Purity
  • Purity >95% by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

BACKGROUND

  • Introduction
  • Dalotuzumab is a humanized monoclonal antibody designed for the treatment of cancers.
  • Antigen Description
  • This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Function
  • ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; nucleo
  • Synonyms
  • IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; MGC142170; MGC142172;

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