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Recombinant humanized (from mouse) antibody expressed in CHO binding to IGF1R. Dalotuzumab is a humanized monoclonal antibody designed for the treatment of cancers.
IgG1 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
Predicted N terminal
Purity >95% by SDS-PAGE.
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Dalotuzumab is a humanized monoclonal antibody designed for the treatment of cancers.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; nucleo