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Recombinant human monoclonal antibody expressed in CHO binding to human IL4R. Anti-IL4R Therapeutic Antibody is a monoclonal antibody designed for the treatment of atopic diseases.
IgG4 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, IHC and most other immunological methods.
Predicted N terminal
>95.0% as determined by analysis by SDS-PAGE.
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Anti-IL4R Therapeutic Antibody is a monoclonal antibody designed for the treatment of atopic diseases.
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
insulin receptor substrate binding; interleukin-4 receptor activity; protein binding; receptor activity; receptor signaling protein activity;