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Anti-IL4R Therapeutic Antibody (TAB-739)

DESCRIPTION CATALOG # SIZE PRICE
Anti-IL4R Therapeutic Antibody TAB-739 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant human monoclonal antibody expressed in CHO binding to human IL4R. Anti-IL4R Therapeutic Antibody is a monoclonal antibody designed for the treatment of atopic diseases.
  • Target
  • IL4R
  • Type
  • IgG4 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, IHC and most other immunological methods.
  • Predicted N terminal
  • EVQLVESG
  • Molecular Weight
  • 146.9 kDa
  • Purity
  • >95.0% as determined by analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

BACKGROUND

  • Introduction
  • Anti-IL4R Therapeutic Antibody is a monoclonal antibody designed for the treatment of atopic diseases.
  • Antigen Description
  • This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
  • Function
  • insulin receptor substrate binding; interleukin-4 receptor activity; protein binding; receptor activity; receptor signaling protein activity;
  • Synonyms
  • IL4R; interleukin 4 receptor; interleukin-4 receptor subunit alpha; CD124; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain; IL4RA; IL-4RA;

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