lirilumab

Cat

TAB-757

Product Overview

Recombinant human monoclonal antibody expressed in CHO binding to human KIRD2 subgroup. Lirilumab is a human monoclonal antibody designed for the treatment of cancer.

Target

KIRD2 subgroup

Type

IgG4 - kappa

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.

CAS

1000676-41-4

Predicted N terminal

QVQLVQSG

Molecular Weight

145.2 kDa

Purity

>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.

Size

1mg

Storage

Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

Introduction

KIRs are human natural killer (NK) cell receptors for MHC class I molecules. Most inhibit the activity of NK cells thus preventing cell lysis. Two main families of receptors for HLA class I have been discovered on human NK cells: Killer cell Immunoglobulin-like receptors (KIR) and CD94/NKG2 heterodimers. The KIR receptors are an extremely diverse family of receptors. In addition to receptors for HLA, NK cells also express pattern recognition receptors e.g. TLRs and Nod proteins.

Antigen Description

Human KIRD2 subgroup (killer cell Immunoglobulin-like Receptor subgroup, including KIR2DL1 (nkat1/CD158A), KIR2DL2 (nkat6/CD158B1), KIR2DL3 (nkat2/CD158B2), KIR2DS1 (CD158H) and KIR2DS2 -nkat5/CD158J-)

Keywords

Killer-cell immunoglobulin-like receptors; KIRs; KIR2DL1/2/3

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