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Recombinant human monoclonal antibody expressed in CHO binding to human PDCD1. Nivolumab is a fully human IgG4 monoclonal antibody for the treatment of cancer. Nivolumab acts as an immunomodulator by blocking ligand activation of the programmed cell death 1 (PD-1) receptor on activated T cells.
IgG4 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
Predicted N terminal
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Nivolumab is a fully human IgG4 monoclonal antibody developed by Bristol-Myers Squibb for the treatment of cancer.
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
protein binding; protein tyrosine phosphatase activity; signal transducer activity;