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Tefibazumab (TAB-029)

DESCRIPTION CATALOG # SIZE PRICE
Anti-S. aureus Therapeutic Antibody (Aurexis) TAB-029 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibodyto Human S. aureus Tefibazumab (marketed under the brand name Aurexis) is a humanized monoclonal antibody for the treatment of severe infections with Staphylococcus aureus. Possible indications include the treatment of S. aureus in patient with cystic fibrosis and of methicillin-resistant S. aureus.
  • Target
  • S. aureus
  • Type
  • IgG1 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • S. aureus
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
  • CAS
  • 521079-87-8
  • Trade name
  • aurexis
  • Specificity
  • Tested positive against native S. aureus antigen.
  • Predicted N terminal
  • H chain: QVQLKESL chain: DIVMTQS
  • Purity
  • Purity >95% by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at -20°C. Avoid multiple freeze/thaw cycles.

BACKGROUND

  • Introduction
  • Humanized monoclonal antibody recognizing clumping factor A expressed by Staphylococcus aureus.
  • Antigen Description
  • S. aureus may occur as a commensal on skin; it also occurs in the nose frequently (in about a third of the population) and the throat less commonly; S. aureus can infect other tissues when barriers have been breached. S. aureus infections may spread through contact with pus from an infected wound, skin-to-skin contact with an infected person by producing hyaluronidase that destroys tissues, and contact with objects such as towels, sheets, clothing, or athletic equipment used by an infected person. Deeply penetrating S. aureus infections can be severe. ClfA is a 92 kDa surface protein identified from S. aureus. ClfA is responsible for the fibrinogen-dependent c1umping of bacteria.
  • Keywords
  • S. aureus; Staphylococcus aureus; ClfA protein; NC_002952.2; Gene ID: 5330438; Tefibazumab; Aurexis

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