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Pritoxaximab (TAB-896)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Shiga toxin 1 B subunit Therapeutic Antibody TAB-896 1mg Please Inquiry

PRODUCT INFORMATION

  • Target
  • Shiga toxin 1 B subunit
  • Type
  • IgG1 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • E. coli
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, IHC and most other immunological methods.
  • CAS
  • 1351470-16-0
  • Predicted N terminal
  • QVQLQESG
  • Molecular Weight
  • Approximately 150 kDa
  • Purity
  • Purity >95% by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

BACKGROUND

  • Introduction
  • Shiga toxins act to inhibit protein synthesis within target cells. The toxin has two subunits designated A and B. The B subunit is a pentamer that binds to specific glycolipids on the host cell, specifically globotriaosylceramide (Gb3).
  • Antigen Description
  • Shiga toxins are a family of related toxins with two major groups, Stx1 and Stx2, expressed by genes considered to be part of the genome of lambdoid prophages. The toxin has two subunits—designated A(mol. wt. 32000 D) and B(mol. wt. 7700 D)—and is one of the AB5 toxins. The B subunit is a pentamer that binds to specific glycolipids on the host cell, specifically globotriaosylceramide (Gb3). Following this, the A subunit is internalised and cleaved into two parts. The A1 component then binds to the ribosome, disrupting protein synthesis.
  • Keywords
  • Shiga toxin 1 B subunit; Shiga toxins

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