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Recombinant mouse monoclonal antibody Fab fragment expressed in CHO binding to human cardiac myosin. Indium (111In) imciromab is a mouse monoclonal antibody and was used for cardiac imaging, but withdrawn in 1993.
Mouse Fab IgG2a - kappa - kappa
The details of the immunogen for this antibody are not available.
Murine ascites, pepsin digestion
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, WB and most other immunological methods.
Approximately 47 kDa
>95.0% as determined by analysis by SDS-PAGE.
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Cardiac MHC exists as two isoforms in humans, alpha-cardiac MHC and beta-cardiac MHC. Th
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.