Creative Biolabs offers professional monoclonal antibody caninization service. Although human therapeutic antibodies have significantly improved human's capacity of fighting diseases, therapeutic antibodies have not made such achievements in pets and other important agriculture animals. Our novel antibody caninization service enables therapeutic use of antibodies derived from any resources for dog use.
Relying on our unparalleled expertise in antibody engineering and affinity maturation, monoclonal antibodies with a variety of species background, such as human, mouse, rabbit, rat, chicken, bovine, can be successfully caninized without specificity switch and with equal or higher affinity than that of original antibody. Antibody caninization is performed using standard CDR grafting method followed by construction and screening of a caninized phage display antibody library with rationally designed back mutations.
Also, antibody caninization service provides the opportunity to test therapeutic antibodies intended for humans and other species in dog animal models. In comparison with tests in rodents, the tests for the caninized form of an original antibody in dogs will produce more relevant data regarding activity, efficacy and safety of the antibody for clinical use. A clearly defined mechanism of action of the caninized antibody in dogs will significantly facilitate drug development and patent application.
Besides antibody caninization services, we are also the only company that provides antibody murinization service and one of the best companies that provides antibody humanization service.