Creative Biolabs offers dual variable domain immunoglobulin (DVD-Ig) production service, which provides immunoglobulin molecules that simultaneously target two mediators of disease by a single pharmaceutical entity. With years of experience in this field, Creative Biolabs has being professional in providing DVD-Ig molecules of reduced potential immunogenicity, full effector functions and robust serum stability.
The DVD-Ig is an IgG-like molecule, except that each light chain and heavy chain contains two variable domains in tandem through a short peptide linkage, instead of one variable domain. They were originally designed for treatment of complex diseases in which multiple mediators contribute to overall disease pathogenesis by distinct or redundant mechanisms, since simultaneous blockade of multiple targets may yield better therapeutic efficacy than inhibition of a single target.
Our services include selection of the VD pairing from parental mAbs, arrangement of the inner/outer orientation of the selected VDs, and determination of the amino acid sequences used to link the VDs. Finally, we provide optimized DVD-Ig molecules, which have many desirable properties of a mAb, such as good expression in mammalian cells, easy purification to homogeneity using standard approaches, etc. Our unique technology has made Creative Biolabs the incomparable supplier of DVD-Ig molecules with good drug-like biophysical and pharmacokinetic properties, and amenable to large-scale manufacturing.