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Featured Conjugation Services

Bioconjugation is a complex process that requires strong knowledge of biology and chemistry. The key to bioconjugation is to maintain the function of its various parts. At Creative Biolabs, our expert scientists have sufficient knowledge of reactive groups, reagent types and functional groups on molecules. We specialize in providing comprehensive bioconjugation services, including biomolecule preparation, modification, conjugation and purification. The final conjugated product is also analyzed and tested with advanced equipment.

Overview of Bioconjugation

Bioconjugation refers to the process of forming a covalent bond between two molecules, at least one of which is a biomolecule. Proteins are important substrates in bioconjugation reactions, which play a key role in protein modification. Common bioconjugation procedures include protein-protein conjugation and protein-to-small molecule coupling. In addition, there are some other molecules in the bioconjugation process, such as nucleic acids, synthetic polymers, and carbon nanotubes.

Antibody-Antibiotic Conjugation

Antibodies are an integral part of biological immunity. Antibody-antibiotic conjugates (AACs) that combine key properties of antibodies and antibiotics have been reported to be effective against specific bacterial infections. AAC consists of three parts: a bactericidal antibiotic payload, an antibody, and a linker that connects the payload to the antibody. The development of AACs offers promising prospects for novel therapies for infectious diseases by combining the pharmacological properties of antibodies and antibiotics into a single molecule.

Structure of an AAC. Fig.1 Structure of an AAC.1

Biotinylation

Biotinylation is the process of coupling biotin to proteins, antibodies, nucleic acids or other molecules. Biotinylation has many advantages. Most importantly, due to the small molecular weight of biotin, it is easy to label target molecules without affecting biological properties. What's more, biotin labeling has the characteristics of high specificity and fast speed. Biotinylation is mainly achieved in two ways: Chemical Biotinylation and Site-specific labeling. Notably, biotinylation levels can be determined by changes in absorbance. Biotinylation is a powerful tool in the identification of protein-protein interactions, post-translational events or drug targets.

Polymer-Drug Conjugates

In recent years, biomolecules such as proteins, peptides, hormones, and enzymes have shown substantial growth as drug candidates. Unfortunately, most biomolecules are characterized by short cycle life and poor stability. To overcome these drawbacks, the protection of biomolecules by covalent binding to other macromolecules is emerging as an attractive strategy. Many polymers are commonly conjugated to biopharmaceutical molecules, such as cellulose derivatives and polyethylene glycol (PEG). Furthermore, dendrimers are essential components in multifunctional drug delivery systems. The final conjugated product has many characteristics, such as reduced immunogenicity, increased drug-targeting specificity and bioavailability.

Custom Bioconjugation Services at Creative Biolabs

Additionally, we offer a wide variety of bioconjugation options, including but not limited to:

Creative Biolabs is a reputable provider of bioconjugation services. Today, we have been supporting customers at the forefront of the development of multiple biomolecular conjugates. Therefore, we are confident to provide satisfactory conjugates according to your unique project requirements. Any questions and requirements, please contact us.

Reference

  1. Cavaco, M.; et al. The use of Antibody-antibiotic conjugates to fight bacterial infections. Frontiers in Microbiology. 2022, 666.


All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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