Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsGiven the importance of membrane protein targets (multi-spanner), private and academic laboratories have tried numerous approaches to raise antibodies against them. The most common way of generating these antibodies is immunization with whole cells over-expressing the target protein. This allows membrane protein targets to be displayed in their native conformation without mechanical or detergent disruption. Typically, stable murine cells expressing a human membrane protein are used to immunize mice. Using this approach, a number of antibodies against highly expressing membrane proteins have been developed. Transiently-transfected cells, membrane preparations, and cells selected for the highest expression levels have been used to improve this approach, with varying degrees of success. However, for many important membrane protein targets the ability of cell-based immunogens to elicit high-quality antibodies has been limited by low membrane-protein expression, the abundance of non-specific proteins, and target protein toxicity during cell line selection.
The other classic approach is to design peptide antigens derived from the extracellular loops for antibody production. Unfortunately, these peptide antigens could not fold in correct tertiary structures as within multi-spanner, thus they are not good for making conformational antibody against multi-spanners.
The overcome this hurdle, we have developed MPAT™ platform (MPAT=Membrane Protein Antibody Technology)
| Immunogen |
Native Conformation |
Immunogen Concentration |
Immunogen Purity |
| Purified Protein | - | +++ | +++ |
|
Reconstituted Protein in Vesicles |
+/- | +++ | +++ |
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
