Modulating Protein Characterization

Creative Biolabs offers customers services for modulating protein characterization to develop or engineer proteins with desired properties. We provide computational protein design techniques, including modulating protein structures, protein intrinsic properties and protein interactions to meet the customers’ specific requirements.

Computational modulation of protein characterization is an important tool for the design of proteins with desired catalytic properties. It can be applied to many fields of protein engineering, including de novo design of protein active sites, optimization of substrate access and product exit pathways, redesign of protein-protein interfaces, identification of advantageous or deleterious mutations in the libraries from directed evolution and stabilization of protein structures.

Protein-protein interactions have been proven important in tuning and regulating most important biological processes, which are involved in disease development. The modulation of protein-protein interactions is thus attracting extensive attention of researchers. The general features of protein-protein interfaces, i.e., the characteristics that make them different from classical protein-ligand binding sites, can be exploited for drug design. Computational methods have been used to study HDM2 and IL-2 for their protein-protein interactions.

Membrane proteins can account for about one third of all proteins in eukaryotic and prokaryotic cells, and they are critical in a diverse array of cellular functions as well. However, they have been much less studied as compared with their water-soluble counterparts, partially due to the lack of effective research tools to study the structure and function of integral membrane proteins. For example, probing agents that can specifically and selectively recognize these targets are still urgently needed. Computational methods for membrane protein property studies can fill up the gap left behind, and provide valuable insight for relevant experimental characterization approaches.

However, there are limitations when using computational modulation methods for protein function studies. Firstly, due to problems with force-field accuracy, we need to rely on diverse computational algorithms for the best solutions. Secondly, modulated protein properties are better to be assessed by biochemical and/or biophysical methods, so as to make the findings conclusive. We can provide excellent computational modulation of the properties of your proteins, and validate the modulated properties using various assays and structural determination techniques.

Services for modulating protein characterization offered by us:

  1. Modulation of Protein Structure
  2. Modulation of Intrinsic Properties by Computational Design
  3. Modulating Protein Interactions by Rational and Computational Design

Figure 1. Schematic representation of proteins structure.

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