Creative Biolabs brings back the classical guinea pig immunization and the novel monoclonal guinea pig antibody production service through our advanced phage display platform. Our global customers are now able to adopt monoclonal guinea pig antibodies with high specificity and affinity for their distinguished researches.
Guinea pig (Cavia porcellus), which is suggested as domesticated descendants of a closely related species of cavy, is a kind of rodent that do not exist naturally in the wild. This species is recognized as one of the earliest used laboratory animals, which has been used in experiments for centuries. From 17th century to the later 20th century, guinea pigs were among the most widely used species in various researches, and even the terms of “experimental animal” and “guinea pig” have been used as synonyms. Same as other rodents, guinea pigs have remarkable biological similarities to humans, which make them useful in various research areas, such as infectious disease studies of tuberculosis and diphtheria and the development of antibodies in response to extreme allergic reactions or anaphylaxis. During the 20th century, because of the lag behind of relevant genetic research, guinea pigs have been gradually replaced by mice and rats from the dominance of experimental animals. However, the species continues to be used in infectious disease studies and other topics, such as immunology.
Compared with other rodents, guinea pigs are more sensitivity, which provides an important feature in the study of human diseases. In addition, the difference of genotype enables guinea pig to generate stronger antibody response to some antigens that are high homology with humans, mouse and rats. For instance, guinea pig insulin has 18 residues differ from human insulin, while there are only 4 residues difference between rat and mice insulin and human insulin, which enable guinea pigs to generate high affinity anti-insulin antibodies. In this way, the production of monoclonal guinea pig antibody may offer novel solutions for some specific targets.
According to the progress of guinea pigs related research, Creative Biolabs can proudly provide novel monoclonal guinea pig antibodies through our well-recognized phage display technology. After routine immunization strategy, our scientists are confident in generating high diversity phage display guinea pig antibody libraries and isolate high specific and affinity monoclonal guinea pig antibodies using biopanning techniques. As alternatives, Creative Biolabs also provides the unique Native™ Guinea Pig Antibody Discovery Service, which is based on antigen-specific B lymphocytes cytometry technology, and Guinea Pig hybridoma development service.
Creative Biolabs is one of the well-recognized provider for high quality monoclonal antibodies. Over the past decade, our devoted scientists have been committed to offering the most comprehensive monoclonal antibodies from various species, which currently involves guinea pig, shark, rabbit, chicken, llama, camel, dog, mouse, rat, human and so on. With years of experience, we are the right company who can generate the desired monoclonal antibodies for your specific demands.