Close

Anti-TcdA Single Domain Antibody (NAB-LXY0008)

DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-C. difficile TcdA Single Domain Antibody NAB-LXY0008 1mg Please Inquiry

PRODUCT INFORMATION

  • Target
  • TcdA
  • Type
  • llama VHH
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • C. difficile
  • Expression Host
  • E.coli
  • Specificity
  • Tested positive against native human antigen.
  • Storage
  • Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

BACKGROUND

  • Antigen Description
  • Clostridium difficile toxin A (TcdA) is a toxin generated by Clostridium difficile. It is similar to Clostridium difficile Toxin B. The toxins are the main virulence factors produced by the gram positive, anaerobic, Clostridium difficile bacteria. The toxins function by damaging the intestinal mucosa and cause the symptoms of C. difficile infection, including pseudomembranous colitis.

    TcdA is one of the largest bacterial toxins known. With a molecular mass of 308kDa, it is usually described as a potent enterotoxin, but it also has some activity as a cytotoxin. The toxin acts by modifying host cell GTPase proteins by glucosylation, leading to changes in cellular activities. Risk factors for C. difficile infection include antibiotic treatment, which can disrupt normal intestinal microbiota and lead to colonization of C. difficile bacteria.
  • Synonyms
  • tcdA; toxA; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium; Clostridium difficile Toxin A

Related Products

Online Inquiry

Verification code
Click image to refresh the verification code.

CONTACT US

45-1 Ramsey Road, Shirley, NY 11967, USA
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us