Anti-TcdA Single Domain Antibody (NAB-LXY0008)
|Recombinant Anti-C. difficile TcdA Single Domain Antibody
- The details of the immunogen for this antibody are not available.
- Species Reactivity
- C. difficile
- Specific Activity
- Tested positive against native human antigen.
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
- Antigen Description
- Clostridium difficile toxin A (TcdA) is a toxin generated by Clostridium difficile. It is similar to Clostridium difficile Toxin B. The toxins are the main virulence factors produced by the gram positive, anaerobic, Clostridium difficile bacteria. The toxins function by damaging the intestinal mucosa and cause the symptoms of C. difficile infection, including pseudomembranous colitis.
TcdA is one of the largest bacterial toxins known. With a molecular mass of 308kDa, it is usually described as a potent enterotoxin, but it also has some activity as a cytotoxin. The toxin acts by modifying host cell GTPase proteins by glucosylation, leading to changes in cellular activities. Risk factors for C. difficile infection include antibiotic treatment, which can disrupt normal intestinal microbiota and lead to colonization of C. difficile bacteria.
- tcdA; toxA; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium; Clostridium difficile Toxin A
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