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Recombinant Human Antibody Fab Fragment binds selectively to Hepatitis B surface antigen, expressed in Chinese Hamster Ovary cells(CHO)
Hepatitis B surface antigen
Fab Fragment based on Human IgG1 - kappa
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
Predicted N terminal
H chain: QVKLLES; L Chain: ELVMTQ
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Store at -20°C. Avoid multiple freeze/thaw cycles.
This is a human monoclonal antibody directed against the hepatitis B virus.
HBV (HBV) infection induces a disease state which manifests itself in a variety of ways, characterized by the extent of liver damage, inflammation and viral persistence. HBV infection is also associated with a 100 fold increased risk of hepatocellular carcinoma and currently infects over 250 million people worldwide. HBV has a partially double stranded 3.2 kilobase DNA genome which contains four open reading frames. One of these encodes a 154 amino acid protein called the HBx protein. HBx has been shown to be a transcriptional transactivator of both viral and cellular promoters. Lacking a DNA binding domain and nuclear localization signal, HBx is believed to exert transcriptional activity through protein protein interaction.
HBsAg; Hep B surface antigen; Hepatitis B Virus major surface antigen; Hepatitis B virus S antigen; Large envelope protein; Large surface protein; LHB; Major surface antigen